The B•R•A•H•M•S MR-proADM KRYPTOR assay is intended for the measurement of MR-proADM which is a fragment of 48 amino acids which splits from proADM molecule in a 1:1 ratio with Adrenomedullin, and therefore proportionally represents the levels and activity of Adrenomedullin. The assay is indicated for use as an aid together with other clinical evaluation and laboratory diagnostic findings to assess outcomes and risk in patients with conditions such as lower respiratory tract infections, urinary tract infections, and kidney disease, as well as in patients suffering from sepsis, severe sepsis, and septic shock. It is also of use in risk assessment in the Emergency Department setting.