The ZEUS AtheNA Multi-Lyte ANA-II Plus Test System is intended for the semi-quantitative detection of IgG class antibody to 8 separate analytes (SSA, SSB, Sm, RNP, Scl-70, Jo-1, Centromere B, and Histone) in human serum, the quantitative detection of IgG class antibody to dsDNA in human serum, and the qualitative detection of IgG class antibody to ANA. This test system is intended to aid in the diagnosis of various systemic autoimmune disorders.